Dr. Arman Rahman, MD, MPH, PhD.
Tel. +353879735320, Email. arman.rahman@ucd.ie
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Biographical sketch:
Dr. Arman Rahman is an MD, Ph.D., he joined the Precision Oncology Ireland (POI) program as a Translational Research and Engagement Manager in February 2020. Dr.Rahman obtained his Ph.D. in Immunology from Umea University, Sweden in 2007. During his post-doctoral fellowship training in Cambridge, UK and DCU, Dublin Dr. Rahman worked extensively with antibody engineering. Since 2012, he is working with Prof. William Gallagher for cancer biomarker development. Dr. Rahman has extensive experience in developing tissue-based assay development (Immunohistochemistry, in situ hybridization) both in academic and commercial research. One of his core expertise is in the area of digital pathology and image analysis in tissue biomarker research. Dr. Rahman is an active member of UCD Patients Voice in Cancer Research and UCD EDI committee. He is working on involving ethnic minority cancer patients in mainstream cancer patients advocacy groups. In 2022 Dr Rahman became a lecturer/ Assistant Professor of Anatomy in the UCD School of Medicine.
Research Interests:
Tumors are intrinsically heterogeneous as cancer cells undergo continuous remodeling to adapt to microenvironmental pressure. Unfortunately, genetic heterogeneity and evolution in tumors are often studied without spatial context. Spatial organization of the intra-tumoral cellular and subcellular machinery is critical for understanding tumor development and progression. Recent developments in automated staining procedures and digital pathology have made tissue-based imaging an attractive tool for biomarker discovery and validation in both academic and commercial research entities. Dr. Rahman has a particular interest in developing tissue-based detection systems such as immunohistochemistry and in situ hybridization as a tool for biomarker discovery and validation. Dr. Rahman is working on the development of new methodologies that combine digital pathology with molecular techniques (e.g. RNAseq and mutation profiling data, etc.) that will enable simultaneous detection of intra-tumoral changes in the context of tumor histology; this will improve our understanding of tumor development and progression and enhance our ability to deliver precision medicine.
Selected publications:
- Rahman, A., Jahangir, C., Lynch, S. M., Alattar, N., Aura, C., Russell, N., . . . Gallagher, W. M. (2020). Advances in tissue-based imaging: impact on oncology research and clinical practice. Expert Rev Mol Diagn, 1-11. doi:10.1080/14737159.2020.1770599
- Gutta C, Rahman A, Aura C et al. Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma. Cell Death Dis, 11(2), 124 (2020).
